The clobenzorex, after oral administration is well absorbed from the gastrointestinal tract, reaches its maximum concentration (Cmax) of one to one and a half after its administration and its concentration varies from 8 to 47 ng / ml. It is excreted in the urine, being one of the main metabolites amphetamine (15% of the administered dose) and p-hidroxiclobenzorex (1.5 to 6% of the administered dose).The clobenzorex is a sympathomimetic amine with pharmacological activity similar to that of other drugs used to treat obesity. It acts on the ventrolateral nucleus of the hypothalamus, increasing the release of norepinephrine and dopamine, and decreases its recapture in presynaptic nerve endings, above, has the effect of increasing concentrations of norepinephrine. Norepinephrine decreases appetite, activating the receptor to-4 And ÃŸ1 in the hypothalamic nuclei.
Units: 30 Tabs
Route of Administration: Oral